A Zombie Gene Keeps Elephants from Getting Cancer | SciShow News
A Zombie Gene Keeps Elephants from Getting Cancer

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Elephants are huge, so you might think all those extra cells would mean more cancer, but scientists have some new insights into why this is isn't the case. Hosted by: Hank Green Head to https://scishowfinds.com/ for hand selected artifacts of the universe! ---------- Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow ---------- Dooblydoo thanks go to the following Patreon supporters: Lazarus G, Sam Lutfi, D.A. Noe, سلطان الخليفي, Piya Shedden, KatieMarie Magnone, Scott Satovsky Jr, Charles Southerland, Patrick D. Ashmore, Tim Curwick, charles george, Kevin Bealer, Chris Peters ---------- Looking for SciShow elsewhere on the internet? Facebook: http://www.facebook.com/scishow Twitter: http://www.twitter.com/scishow Tumblr: http://scishow.tumblr.com Instagram: http://instagram.com/thescishow ---------- Sources: https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31145-8 https://www.eurekalert.org/emb_releases/2018-08/uocm-zgp080818.php https://www.eurekalert.org/emb_releases/2018-08/cp-erc080718.php https://lynchlab.uchicago.edu/ https://www.nature.com/news/how-elephants-avoid-cancer-1.18534 https://www.quantamagazine.org/a-zombie-gene-protects-elephants-from-cancer-20171107/ https://jamanetwork.com/journals/jama/fullarticle/2456041 https://elifesciences.org/articles/11994 http://animals.sandiegozoo.org/animals/rock-hyrax Thumbnail Image: https://commons.wikimedia.org/wiki/File:Eye_of_the_elephant_(Unsplash).jpg

Comments

Sebastian Elytron : Went shopping today and left my new expensive Levi's in the car. Like elephants, I have special jeans in my trunk.

Master Therion : We should make a vaccine against cancer using CRISPR and the LIF gene. But, just for laughs, let's not call it "Leukemia inhibitory factor." Let's call it the Zombie Gene just to freak people out.

Orion Fyre : "Zombie genes" a name chosen for the explicit purpose of garnering public attention through news editors slapping front page headlines like "Elephants protected from cancer by ancient zombie gene."

Cat Man : How do you tell if a cell is male or female? By pulling down it's genes. Okay that was bad and old!!!

Stothehighest : I gotta ask, just who and why does someone downvote this? I think it was a pretty good video, didn't leave any strings dangling and wasn't clickbait.

Ionizationism_is_a_thing 05 : Before video: why can't we have them? After video: Wow, elephants are cool.

Best Dad ⵣ : This gene should be used with CRISPR to combat cancer in Humans. Kinda ironic that Elephants would save us indirectly before we kill them all off.

Tim Buchanan : You forgot about the gene Ligma-9

LOVE OF PLANTS 🌻 : Elephants may survive cancerous cells but it’s likely they won’t survive the Anthropocene.

Minnesota Acoustic : You thought sitting next to a baby on a plane was bad, try a zombie elephant and youre the only guy with nuts. Not good.

crovax 13 : I suppose that large dinosaurs would have had similar defenses against cancer cells

Curiosity Culture : This makes me happy! Elephants are the best animal, they deserve this! ❤️

Justin Y. : I have no joke, this is pretty interesting!

ursaltydog : What if these genes were spliced into our genome?

shmuckling : In a few decades there will be Humans and possibly some animals that will be modified to be mostly immune to cancer. This discovery also shows how important is to conserve the variety in life species - of all the animals that had these genes and could have been studied, only Elephants survive and they're not doing too hot either. If they would have went extinct too we likely would have never known about this and it could turn out to be one of our greatest discoveries.

Infernoraptor : "Long-lived creatures like bats" ?!? Didn't know about that. (Out of context, I'd be more likely to assume that's some sort of vampire joke.) Surely such active animals must have fast metabolisms and die quickly right? *checks google* 30 years?! Wow!

David B : My Grandmother loved elephants (considering the amount of elephant-themed art and furniture, probably too much) so I always love to learn about how awesome elephants really are.

WarlockofWordsReturns RB : Mole rats seem immune from cancer, too. Study the hell out of elephants and mole rats, scientists!

Viggo Malvenius : You spent far too little time on how ELEPHANTS AND SEA COWS ARE CLOSELY RELATED TO LITTLE RABBIT ISH THINGS!!!!!!!!!!!!!! Wtf nature!!!!!!!!

Camkitsune : Peto's Paradox isn't really a paradox at all, it's just something that initially seems counter-intuitive if you don't account for Natural Selection. 1) Large animals generally require more resources to live in day-to-day terms. 2) Because of this additional demand offspring tend to be birthed in smaller numbers so that the parents can take better care of them - and so that they are less likely to immediately overwhelm the local carrying capacity and starve everyone in their niche to death. Evolutionary lines that do _not_ do this are extremely unlikely to survive for long. 3) Because of the low birth rate, natural selection tends to favor longer life spans and longer windows of fertility. 4) The factors of 'large', 'long life span' and 'low birth rate' all strongly favor selection for genes that are cancer-resistant. Animals that get cancer and die before breeding enough times to maintain their 'market share' of the gene pool will ultimately be out-competed by the ones that don't, and eventually become phased out. 5) The combination of 'large' and 'long-lived' means that the animal's genes will both be resistant to copying errors (selected for by the higher copy rate) and to degradation (selected for by the longer window of fertility).

McKinley Griggs : Who else likes the way Hank says *duplication* ?

Rebecca Barnå : This is so cool! Go elephants 😄

ridiculous red : I seen people hate on Hank and sci show but for real I'm glad their doing what their doing thank you all !

YOWHAZGOOD : mitochondria is the muscle hank of the cell

James Morgan : Do you even LIF?

RadicalErin : You would expect bigger animals with more cells to get cancer more often, which in turn leads to the expectation that they would find ways to handle it explicitly /because/ they are bigger and have more cells, thereby requiring it in order to maintain a remotely viable species.

BadCobra38 : Shouldn’t it be called a Deadpool gene

Olympias : "Zombification" Somehow, I like the sound of that...

Ethan Blanke : Question: are there any obvious adverse effects that would occur if humans possessed these genes and their functionality? I don’t see any but I know genetics is a complicated subject

Dr. Dacus : "It's killer, but, you know... the helpful kind of killing." What does THAT mean, Hank?

Gothead420 : Oh Hank, i would have loved you as my professor in phytopathology! ^^

Michelle Speed : Rock hyrax sounds like something from a Legend of Zelda game.

TheMissMaggs : "The HELPFUL kind of killing".... I LOVE that!!!

Pranav Limaye : *You wore the same t-shirt over on SciShow Space!!!* My man.

Aniket Lahiri : Hey guys! Love your work. But it seems mostly biology or chemistry, would love to see more of physics!

Dan Al : Now I could totally imagine a resource management game for the promotion of elephant protection, titled "LIF6: Mother Instinct".

scabiniful : i was too distracted by blurry pizza john, it makes my brain do weird things

Staring at the Black Sun Trying to SEE THE LIGHT : This was massively informative on so many levels. Thanks, science people guys! You, guys!

Tark McCoy : "...but it's a helpful kind of killing" I'm going to add that to my hitman calling card.

Vilhelmo De Okcidento : Aging is programmed. Immortality seems to be, in most environment, maladaptive.

Tyler Martin : Thanks for making me look up how long bats live! 20-40 years: That's bananas!

Lightwish Light : Fascinating information. Hopefully scientists can find a way to make this into a type of anti-cancer treatment.

Bradley Watson : I'm confused by your pixel-ated pizza face t-shirt and the zombie related gene talk. Very distracting. Rock Hyrax relatives rule!

shuushirakawa : 0:17 I was listening to this in the background and suddenly had to look at the video to make sure I misheard it. I did mishear it.

Kishore Shenoy : Don't insects get tumours? If they do, will it be malignANT?

Rik Wisselink : That shirt looks really 3D with the video interlacing when he moves...

Not Your Everyday Timelord : THE MITOCHONDRIA IS THE POWERHOUSE OF THE CELL

JUST 2HI4U : *Reads the title card* ... EXCUSE ME?!

mythology2467 : That's some nice John you're rocking Hank